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Brain Distribution and Active Efflux of Three panRAF Inhibitors: Considerations in the Treatment of Melanoma Brain Metastases
Targeted inhibition of RAF and MEK by molecularly targeted agents has been employed as a strategy to block aberrant mitogen-activated protein kinase (MAPK) signaling in melanoma. While the use of BRAF and MEK inhibitors, either as a single agent or in combination, improved efficacy in BRAF-mutant me...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Pharmacol Exp Ther |
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| Κύριοι συγγραφείς: | , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6374543/ https://ncbi.nlm.nih.gov/pubmed/30622172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.253708 |
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