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Development and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability

The study objective was to develop a formulation of elacridar to overcome its dissolution-rate limited bioavailability. Elacridar is a P-gp and BCRP inhibitor that has been used to improve the brain distribution of drugs that are substrates of P-gp and BCRP. The chronic use of elacridar is restricte...

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Main Authors: Sane, Ramola, Mittapalli, Rajendar K., Elmquist, William F.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967790/
https://ncbi.nlm.nih.gov/pubmed/23334925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23450
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