Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate

Tenofovir disoproxil fumarate (TDF), the bisphosphonate ester prodrug of tenofovir (TFV), has poor bioavailability due to intestinal degradation and efflux transport. Reformulation using U.S. Food and Drug Administration–approved esterase and efflux inhibitors to increase oral bioavailability could...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Watkins, Melynda E., Wring, Steve, Randolph, Ryan, Park, Seonghee, Powell, Kendall, Lutz, Lissa, Nowakowski, Michelle, Ramabhadran, Ram, Domanico, Paul L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320394/
https://ncbi.nlm.nih.gov/pubmed/27986599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.12.003
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