Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate

Tenofovir disoproxil fumarate (TDF), the bisphosphonate ester prodrug of tenofovir (TFV), has poor bioavailability due to intestinal degradation and efflux transport. Reformulation using U.S. Food and Drug Administration–approved esterase and efflux inhibitors to increase oral bioavailability could...

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Bibliographic Details
Published in:J Pharm Sci
Main Authors: Watkins, Melynda E., Wring, Steve, Randolph, Ryan, Park, Seonghee, Powell, Kendall, Lutz, Lissa, Nowakowski, Michelle, Ramabhadran, Ram, Domanico, Paul L.
Format: Artigo
Language:Inglês
Published: Elsevier 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320394/
https://ncbi.nlm.nih.gov/pubmed/27986599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.12.003
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