Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate

Tenofovir disoproxil fumarate (TDF), a prodrug of tenofovir, has oral bioavailability (25%) limited by intestinal transport (P-glycoprotein), and intestinal degradation (carboxylesterase). However, the influence of luminal pancreatic enzymes is not fully understood. Physiologically based pharmacokin...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Moss, Darren M., Domanico, Paul, Watkins, Melynda, Park, Seonghee, Randolph, Ryan, Wring, Steve, Rajoli, Rajith Kumar Reddy, Hobson, James, Rannard, Steve, Siccardi, Marco, Owen, Andrew
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487657/
https://ncbi.nlm.nih.gov/pubmed/28416547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00105-17
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