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Pharmacokinetic Assessment of Efflux Transport in Sunitinib Distribution to the Brain
This study quantitatively assessed transport mechanisms that limit the brain distribution of sunitinib and investigated adjuvant strategies to improve its brain delivery for the treatment of glioblastoma multiforme (GBM). Sunitinib has not shown significant activity in GBM clinical trials, despite p...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3836310/ https://ncbi.nlm.nih.gov/pubmed/24113148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.208959 |
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