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Pharmacokinetic Assessment of Efflux Transport in Sunitinib Distribution to the Brain

This study quantitatively assessed transport mechanisms that limit the brain distribution of sunitinib and investigated adjuvant strategies to improve its brain delivery for the treatment of glioblastoma multiforme (GBM). Sunitinib has not shown significant activity in GBM clinical trials, despite p...

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書目詳細資料
Main Authors: Oberoi, Rajneet K., Mittapalli, Rajendar K., Elmquist, William F.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836310/
https://ncbi.nlm.nih.gov/pubmed/24113148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.208959
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