Efflux Transporters at the Blood-Brain Barrier Limit Delivery and Efficacy of Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib (PD-0332991) in an Orthotopic Brain Tumor Model

6-Acetyl-8-cyclopentyl-5-methyl-2-([5-(piperazin-1-yl)pyridin-2-yl]amino)pyrido(2,3-d)pyrimidin-7(8H)-one [palbociclib (PD-0332991)] is a cyclin-dependent kinase 4/6 inhibitor approved for the treatment of metastatic breast cancer and is currently undergoing clinical trials for many solid tumors. Gl...

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Bibliografiska uppgifter
I publikationen:J Pharmacol Exp Ther
Huvudupphovsmän: Parrish, Karen E., Pokorny, Jenny, Mittapalli, Rajendar K., Bakken, Katrina, Sarkaria, Jann N., Elmquist, William F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2015
Ämnen:
Metabolism, Transport, and Pharmacogenomics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613960/
https://ncbi.nlm.nih.gov/pubmed/26354993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.228213
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