INFLUENCE OF DRUG DELIVERY ON THERAPEUTIC BENEFIT IN GBM–CDK4 AND MDM2 INHIBITOR COMPARISON IN FLANK VERSUS ORTHOTOPIC MODELS AND COMPARISON OF BRAIN PENETRANT VERSUS IMPENETRANT PI3K/MTOR INHIBITORS

BACKGROUND: Insufficient drug delivery across an intact blood-brain barrier (BBB) may limit the efficacy of therapeutic strategies. This study tested whether penetration across the BBB in glioblastoma could affect the efficacy of promising therapies. METHODS: The efficacy of a CDK4 inhibitor (PD0332...

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Detalhes bibliográficos
Main Authors: Sarkaria, Jann N., Pokorny, Jenny L., Mladek, Ann C., Parrish, Karen, Oberoi, Rajneet, Sio, Terence, Mittapalli, Rajendar K., Elmquist, William F.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144587/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.40
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