Efflux Transporters at the Blood-Brain Barrier Limit Delivery and Efficacy of Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib (PD-0332991) in an Orthotopic Brain Tumor Model

Por Parrish, Karen E., Pokorny, Jenny, Mittapalli, Rajendar K., Bakken, Katrina, Sarkaria, Jann N., Elmquist, William F.
Publicado no J Pharmacol Exp Ther (2015)

Strategies to improve delivery of anticancer drugs across the blood–brain barrier to treat glioblastoma

Por Oberoi, Rajneet K., Parrish, Karen E., Sio, Terence T., Mittapalli, Rajendar K., Elmquist, William F., Sarkaria, Jann N.
Publicado no Neuro Oncol (2016)

INFLUENCE OF DRUG DELIVERY ON THERAPEUTIC BENEFIT IN GBM–CDK4 AND MDM2 INHIBITOR COMPARISON IN FLANK VERSUS ORTHOTOPIC MODELS AND COMPARISON OF BRAIN PENETRANT VERSUS IMPENETRANT P...

Por Sarkaria, Jann N., Pokorny, Jenny L., Mladek, Ann C., Parrish, Karen, Oberoi, Rajneet, Sio, Terence, Mittapalli, Rajendar K., Elmquist, William F.
Publicado em 2014

ABCG2 and ABCB1 limit the efficacy of dasatinib in a PDGF-B driven brainstem glioma model

Por Mittapalli, Rajendar K, Chung, Alexander H, Parrish, Karen E, Crabtree, Donna, Halvorson, Kyle G., Hu, Guo, Elmquist, William F, Becher, Oren J
Publicado no Mol Cancer Ther (2016)

Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Res...

Por Vaidhyanathan, Shruthi, Wilken-Resman, Brynna, Ma, Daniel J., Parrish, Karen E., Mittapalli, Rajendar K., Carlson, Brett L., Sarkaria, Jann N., Elmquist, William F.
Publicado no J Pharmacol Exp Ther (2016)

Efficacy of PARP inhibitor rucaparib in orthotopic glioblastoma xenografts is limited by ineffective drug penetration into the central nervous system

Por Parrish, Karen E., Cen, Ling, Murray, James, Calligaris, David, Kizilbash, Sani, Mittapalli, Rajendar K., Carlson, Brett L., Schroeder, Mark A., Sludden, Julieann, Boddy, Alan V., Agar, Nathalie Y.R., Curtin, Nicola J., Elmquist, William F., Sarkaria, Jann N.
Publicado no Mol Cancer Ther (2015)