Efficacy of PARP inhibitor rucaparib in orthotopic glioblastoma xenografts is limited by ineffective drug penetration into the central nervous system

Poly (ADP-ribose) polymerase (PARP) inhibition can enhance the efficacy of temozolomide (TMZ) and prolong survival in orthotopic glioblastoma (GBM) xenografts. The aim of this study was to evaluate the combination of the PARP inhibitor rucaparib with TMZ and to correlate pharmacokinetic and pharmaco...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Parrish, Karen E., Cen, Ling, Murray, James, Calligaris, David, Kizilbash, Sani, Mittapalli, Rajendar K., Carlson, Brett L., Schroeder, Mark A., Sludden, Julieann, Boddy, Alan V., Agar, Nathalie Y.R., Curtin, Nicola J., Elmquist, William F., Sarkaria, Jann N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674360/
https://ncbi.nlm.nih.gov/pubmed/26438157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0553
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