Development and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability

Por Sane, Ramola, Mittapalli, Rajendar K., Elmquist, William F.
Publicado em 2013

Pharmacokinetic Assessment of Efflux Transport in Sunitinib Distribution to the Brain

Por Oberoi, Rajneet K., Mittapalli, Rajendar K., Elmquist, William F.
Publicado em 2013

Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on the Brain Distribution of a Novel BRAF Inhibitor: Vemurafenib (PLX4032)

Por Mittapalli, Rajendar K., Vaidhyanathan, Shruthi, Sane, Ramola, Elmquist, William F.
Publicado em 2012

Saturable Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier Leads to Nonlinear Distribution of Elacridar to the Central Nervous System

Por Sane, Ramola, Agarwal, Sagar, Mittapalli, Rajendar K., Elmquist, William F.
Publicado em 2013

Mechanisms Limiting Distribution of the Threonine-Protein Kinase B-RaF(V600E) Inhibitor Dabrafenib to the Brain: Implications for the Treatment of Melanoma Brain Metastases

Por Mittapalli, Rajendar K., Vaidhyanathan, Shruthi, Dudek, Arkadiusz Z., Elmquist, William F.
Publicado em 2013

Sunitinib LC–MS/MS Assay in Mouse Plasma and Brain Tissue: Application in CNS Distribution Studies

Por Oberoi, Rajneet K., Mittapalli, Rajendar K., Fisher, James, Elmquist, William F.
Publicado em 2013

Factors Influencing the CNS Distribution of a Novel MEK-1/2 Inhibitor: Implications for Combination Therapy for Melanoma Brain Metastases

Por Vaidhyanathan, Shruthi, Mittapalli, Rajendar K., Sarkaria, Jann N., Elmquist, William F.
Publicado em 2014

Quantitative Proteomics of Transporter Expression in Brain Capillary Endothelial Cells Isolated from P-Glycoprotein (P-gp), Breast Cancer Resistance Protein (Bcrp), and P-gp/Bcrp K...

Por Agarwal, Sagar, Uchida, Yasuo, Mittapalli, Rajendar K., Sane, Ramola, Terasaki, Tetsuya, Elmquist, William F.
Publicado em 2012

Quantitative fluorescence microscopy provides high resolution imaging of passive diffusion and P-gp mediated efflux at the in vivo blood–brain barrier

Por Mittapalli, Rajendar K., Manda, Vamshi K., Bohn, Kaci A., Adkins, Chris E., Lockman, Paul R.
Publicado no J Neurosci Methods (2013)

Efflux Transporters at the Blood-Brain Barrier Limit Delivery and Efficacy of Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib (PD-0332991) in an Orthotopic Brain Tumor Model

Por Parrish, Karen E., Pokorny, Jenny, Mittapalli, Rajendar K., Bakken, Katrina, Sarkaria, Jann N., Elmquist, William F.
Publicado no J Pharmacol Exp Ther (2015)

bis-Pyridinium Cyclophanes: Novel Ligands with High Affinity for the Blood-Brain Barrier Choline Transporter

Por Zhang, Zhenfa, Lockman, Paul R., Mittapalli, Rajendar K., Allen, David D., Dwoskin, Linda P., Crooks, Peter A.
Publicado em 2008

Strategies to improve delivery of anticancer drugs across the blood–brain barrier to treat glioblastoma

Por Oberoi, Rajneet K., Parrish, Karen E., Sio, Terence T., Mittapalli, Rajendar K., Elmquist, William F., Sarkaria, Jann N.
Publicado no Neuro Oncol (2016)

Quantitative fluorescent microscopy measures vascular pore size in primary and metastatic brain tumors

Por Mittapalli, Rajendar K, Adkins, Chris E, Bohn, Kaci. A., Mohammad, Afroz, Lockman, Julie A, Lockman, Paul R
Publicado no Cancer Res (2016)

Brain metastases from renal cell carcinoma in the era of tyrosine kinase inhibitors

Por Dudek, Arkadiusz Z., Raza, Ahmad, Chi, Ming, Singhal, Meghali, Oberoi, Rajneet, Mittapalli, Rajendar K., Agarwal, Sagar, Elmquist, William F.
Publicado no Clin Genitourin Cancer (2012)

A novel preclinical method to quantitatively evaluate early-stage metastatic events at the murine blood-brain barrier

Por Adkins, Chris E, Nounou, Mohamed I, Mittapalli, Rajendar K, Terrell-Hall, Tori B, Mohammad, Afroz S, Jagannathan, Rajaganapathi, Lockman, Paul R
Publicado no Cancer Prev Res (Phila) (2014)

INFLUENCE OF DRUG DELIVERY ON THERAPEUTIC BENEFIT IN GBM–CDK4 AND MDM2 INHIBITOR COMPARISON IN FLANK VERSUS ORTHOTOPIC MODELS AND COMPARISON OF BRAIN PENETRANT VERSUS IMPENETRANT P...

Por Sarkaria, Jann N., Pokorny, Jenny L., Mladek, Ann C., Parrish, Karen, Oberoi, Rajneet, Sio, Terence, Mittapalli, Rajendar K., Elmquist, William F.
Publicado em 2014

ABCG2 and ABCB1 limit the efficacy of dasatinib in a PDGF-B driven brainstem glioma model

Por Mittapalli, Rajendar K, Chung, Alexander H, Parrish, Karen E, Crabtree, Donna, Halvorson, Kyle G., Hu, Guo, Elmquist, William F, Becher, Oren J
Publicado no Mol Cancer Ther (2016)

Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Res...

Por Vaidhyanathan, Shruthi, Wilken-Resman, Brynna, Ma, Daniel J., Parrish, Karen E., Mittapalli, Rajendar K., Carlson, Brett L., Sarkaria, Jann N., Elmquist, William F.
Publicado no J Pharmacol Exp Ther (2016)

Predictive Screening Model for Potential Vector-Mediated Transport of Cationic Substrates at the Blood-Brain Barrier Choline Transporter

Por Geldenhuys, Werner J., Manda, Vamshi K., Mittapalli, Rajendar K., Van der Schyf, Cornelis J., Crooks, Peter A., Dwoskin, Linda P., Allen, David D., Lockman, Paul R.
Publicado em 2009

Semi-automated Rapid Quantification of Brain Vessel Density Utilizing Fluorescent Microscopy

Por Bohn, Kaci A., Adkins, Chris E., Mittapalli, Rajendar K., Terrell-Hall, Tori B., Mohammad, Afroz S., Shah, Neal, Dolan, Emma L., Nounou, Mohamed I., Lockman, Paul R.
Publicado no J Neurosci Methods (2016)