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Brain Distribution of Cediranib Is Limited by Active Efflux at the Blood-Brain Barrier

Cediranib is an orally active tyrosine kinase inhibitor that targets the vascular endothelial growth factor receptor family. Because of its potent antiangiogenic and antitumor activities, cediranib has been evaluated for therapy in glioma, a primary brain tumor. This study investigated the influence...

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書目詳細資料
Main Authors: Wang, Tianli, Agarwal, Sagar, Elmquist, William F.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2012
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336816/
https://ncbi.nlm.nih.gov/pubmed/22323823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.190488
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