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Brain Distribution of Cediranib Is Limited by Active Efflux at the Blood-Brain Barrier
Cediranib is an orally active tyrosine kinase inhibitor that targets the vascular endothelial growth factor receptor family. Because of its potent antiangiogenic and antitumor activities, cediranib has been evaluated for therapy in glioma, a primary brain tumor. This study investigated the influence...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3336816/ https://ncbi.nlm.nih.gov/pubmed/22323823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.190488 |
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