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Targeting Radiation-Induced G(2) Checkpoint Activation with the Wee-1 Inhibitor MK-1775 in Glioblastoma Cell Lines

The purpose of this study was to determine the capacity of MK-1775, a potent Wee-1 inhibitor, to abrogate the radiation-induced G(2) checkpoint arrest and modulate radiosensitivity in glioblastoma cell models and normal human astrocytes. The radiation-induced checkpoint response of established gliob...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Sarcar, Bhaswati, Kahali, Soumen, Prabhu, Antony H., Shumway, Stuart D., Xu, Yang, Demuth, Tim, Chinnaiyan, Prakash
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753756/
https://ncbi.nlm.nih.gov/pubmed/21992793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0469
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