Tryptophan metabolism contributes to radiation-induced immune checkpoint reactivation in glioblastoma

PURPOSE: Immune checkpoint inhibitors designed to revert tumor-induced immune suppression have emerged as potent anti-cancer therapies. Tryptophan metabolism represents an immune checkpoint and targeting this pathway’s rate limiting enzyme IDO1 is actively being investigated clinically. Here, we stu...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Kesarwani, Pravin, Prabhu, Antony, Kant, Shiva, Kumar, Praveen, Graham, Stewart F., Buelow, Katie, Wilson, George, Miller, C. Ryan, Chinnaiyan, Prakash
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591719/
https://ncbi.nlm.nih.gov/pubmed/29691296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0041
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