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Tryptophan metabolism contributes to radiation-induced immune checkpoint reactivation in glioblastoma
PURPOSE: Immune checkpoint inhibitors designed to revert tumor-induced immune suppression have emerged as potent anti-cancer therapies. Tryptophan metabolism represents an immune checkpoint and targeting this pathway’s rate limiting enzyme IDO1 is actively being investigated clinically. Here, we stu...
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| Publicat a: | Clin Cancer Res |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6591719/ https://ncbi.nlm.nih.gov/pubmed/29691296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0041 |
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