WEE1 inhibition by MK1775 as a single-agent therapy inhibits ovarian cancer viability

Wee1-like protein kinase (WEE1) physiologically serves a key function in maintaining the integrity of the cell genome through mediating the activation of cyclin-dependent kinase (CDK)1 and CDK2. Increased expression of WEE1 has been associated with the poor prognosis of patients with ovarian cancer....

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Veröffentlicht in:Oncol Lett
Hauptverfasser: Zhang, Minghui, Dominguez, Donye, Chen, Siqi, Fan, Jie, Qin, Lei, Long, Alan, Li, Xia, Zhang, Yi, Shi, Huirong, Zhang, Bin
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588002/
https://ncbi.nlm.nih.gov/pubmed/28927115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.6584
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