Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas

Sarcomas are rare and heterogeneous mesenchymal tumors affecting both pediatric and adult populations with more than 70 recognized histologies. Doxorubicin and ifosfamide have been the main course of therapy for treatment of sarcomas; however, the response rate to these therapies is about 10–20% in...

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Main Authors: Kreahling, Jenny M., Foroutan, Parastou, Reed, Damon, Martinez, Gary, Razabdouski, Tiffany, Bui, Marilyn M., Raghavan, Meera, Letson, Douglas, Gillies, Robert J., Altiok, Soner
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592874/
https://ncbi.nlm.nih.gov/pubmed/23520471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057523
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