p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775

The Wee1 inhibitor MK1775 (AZD1775) is currently being tested in clinical trials for cancer treatment. Here, we show that the p53 target and CDK inhibitor p21 protects against MK1775-induced DNA damage during S-phase. Cancer and normal cells deficient for p21 (HCT116 p21(-/-), RPE p21(-/-), and U2OS...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Hauge, Sissel, Macurek, Libor, Syljuåsen, Randi G.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527284/
https://ncbi.nlm.nih.gov/pubmed/30943845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2019.1593649
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