Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading

Recent studies have shown synergistic cytotoxic effects of simultaneous Chk1- and Wee1-inhibition. However, the mechanisms behind this synergy are not known. Here, we present a flow cytometry-based screen for compounds that cause increased DNA damage in S-phase when combined with the Wee1-inhibitor...

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Publicat a:Oncotarget
Autors principals: Hauge, Sissel, Naucke, Christian, Hasvold, Grete, Joel, Mrinal, Rødland, Gro Elise, Juzenas, Petras, Stokke, Trond, Syljuåsen, Randi G.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
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Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355238/
https://ncbi.nlm.nih.gov/pubmed/28030798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14089
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