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MK-1775, a Novel Wee1 Kinase Inhibitor, Radiosensitizes p53-defective Human Tumor Cells

PURPOSE: Radiotherapy is commonly used to treat a variety of solid tumors. However, improvements in the therapeutic ratio for several disease sites are sorely needed leading us to assess molecularly targeted therapeutics as radiosensitizers. The aim of this study was to assess the wee1 kinase inhibi...

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Detalhes bibliográficos
Main Authors: Bridges, Kathleen A., Hirai, Hiroshi, Buser, Carolyn A., Brooks, Colin, Liu, Huifeng, Buchholz, Thomas A., Molkentine, Jessica M., Mason, Kathryn A., Meyn, Raymond E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167033/
https://ncbi.nlm.nih.gov/pubmed/21799033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0650
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