MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells

Radiotherapy is commonly used to treat a variety of solid tumors but improvements in the therapeutic ratio are sorely needed. The aim of this study was to assess the Chk1 kinase inhibitor, MK-8776, for its ability to radiosensitize human tumor cells. Cells derived from NSCLC and HNSCC cancers were t...

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Опубликовано в: :Oncotarget
Главные авторы: Bridges, Kathleen A., Chen, Xingxing, Liu, Huifeng, Rock, Crosby, Buchholz, Thomas A., Shumway, Stuart D., Skinner, Heath D., Meyn, Raymond E.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342109/
https://ncbi.nlm.nih.gov/pubmed/27690219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12311
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