The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy

MK-8776 is a recently described inhibitor that is highly selective for checkpoint kinase 1 (Chk1), which can weaken the DNA repair capacity in cancer cells to achieve chemo-sensitization. A number of studies show that MK-8776 enhances the cytotoxicity of hydroxyurea and gemcitabine without increasin...

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Publicat a:Acta Pharmacol Sin
Autors principals: Zhou, Zhi-rui, Yang, Zhao-zhi, Wang, Shao-jia, Zhang, Li, Luo, Ju-rui, Feng, Yan, Yu, Xiao-li, Chen, Xing-xing, Guo, Xiao-mao
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386307/
https://ncbi.nlm.nih.gov/pubmed/28042876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.136
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