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Comparative Activity and Off-Target Effects in Cells of the CHK1 Inhibitors MK-8776, SRA737, and LY2606368
[Image: see text] DNA damage activates the checkpoint protein CHK1 to arrest cell cycle progression, providing time for repair and recovery. Consequently, inhibitors of CHK1 (CHK1i) enhance damage-induced cell death. Additionally, CHK1i elicits single agent cytotoxicity in some cell lines. We compar...
Shranjeno v:
| izdano v: | ACS Pharmacol Transl Sci |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American
Chemical Society
2021
|
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8033610/ https://ncbi.nlm.nih.gov/pubmed/33860197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00201 |
| Oznake: |
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