Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor, MK8776

PURPOSE: The combination of radiation with chemotherapy is the most effective therapy for unresectable pancreatic cancer. To improve upon this regimen, we combined the selective Chk1 inhibitor, MK8776 with gemcitabine-based chemoradiation in preclinical pancreatic cancer models. EXPERIMENTAL DESIGN:...

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Detalhes bibliográficos
Main Authors: Engelke, Carl G., Parsels, Leslie A., Qian, Yushen, Zhang, Qiang, Karnak, David, Robertson, Jordan R., Tanska, Daria M., Wei, Dongping, Davis, Mary A., Parsels, Joshua D., Zhao, Lili, Greenson, Joel K, Lawrence, Theodore S., Maybaum, Jonathan, Morgan, Meredith A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745540/
https://ncbi.nlm.nih.gov/pubmed/23804422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3748
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