Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry

In order to determine the relative contribution of checkpoint abrogation and subsequent aberrant mitotic entry to gemcitabine chemosensitization by CHK1 inhibition, we established a model utilizing the CDK inhibitors roscovitine or purvalanol A to re-establish cell cycle arrest and prevent aberrant...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Cycle
Egile Nagusiak: Parsels, Leslie A., Tanska, Daria M., Parsels, Joshua D., Zabludoff, Sonya D., Cuneo, Kyle C., Lawrence, Theodore S., Maybaum, Jonathan, Morgan, Meredith A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2016
Gaiak:
Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845922/
https://ncbi.nlm.nih.gov/pubmed/26890478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1148841
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