Gemcitabine sensitization by Chk1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

The protein kinase Chk1 has been implicated as a key regulator of cell cycle progression and DNA repair and inhibitors of Chk1 (e.g., UCN-01, EXEL-9844) potentiate the cytotoxic actions of chemotherapeutic drugs in tumor cells. We have examined the ability of PD-321852, a small-molecule Chk1 inhibit...

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Main Authors: Parsels, Leslie A., Morgan, Meredith A., Tanska, Daria M., Parsels, Joshua D., Palmer, Brian D., Booth, R. John, Denny, William A., Canman, Christine E., Kraker, Alan J., Lawrence, Theodore S., Maybaum, Jonathan
格式: Artigo
語言:Inglês
出版: 2009
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730564/
https://ncbi.nlm.nih.gov/pubmed/19139112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0662
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