Sensitization of Pancreatic Cancer Stem Cells to Gemcitabine by Chk1 Inhibition

Checkpoint kinase 1 (Chk1) inhibition sensitizes pancreatic cancer cells and tumors to gemcitabine. We hypothesized that Chk1 inhibition would sensitize pancreatic cancer stem cells to gemcitabine. We tested this hypothesis by using two patient-derived xenograft models (designated J and F) and the p...

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Hauptverfasser: Venkatesha, Venkatasubbaiah A, Parsels, Leslie A, Parsels, Joshua D, Zhao, Lili, Zabludoff, Sonya D, Simeone, Diane M, Maybaum, Jonathan, Lawrence, Theodore S, Morgan, Meredith A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press Inc. 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394194/
https://ncbi.nlm.nih.gov/pubmed/22787433
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