Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair()()

To improve the efficacy of chemoradiation therapy for locally advanced pancreatic cancer and begin to establish patient selection criteria, we investigated the combination of the WEE1 inhibitor AZD1775 with gemcitabine-radiation in homologous recombination (HR) repair proficient and deficient pancre...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neoplasia
Prif Awduron: Kausar, Tasneem, Schreiber, Jason S., Karnak, David, Parsels, Leslie A., Parsels, Joshua D., Davis, Mary A., Zhao, Lili, Maybaum, Jonathan, Lawrence, Theodore S., Morgan, Meredith A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Neoplasia Press 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656803/
https://ncbi.nlm.nih.gov/pubmed/26585231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2015.09.006
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