Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair()()

To improve the efficacy of chemoradiation therapy for locally advanced pancreatic cancer and begin to establish patient selection criteria, we investigated the combination of the WEE1 inhibitor AZD1775 with gemcitabine-radiation in homologous recombination (HR) repair proficient and deficient pancre...

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Détails bibliographiques
Publié dans:Neoplasia
Auteurs principaux: Kausar, Tasneem, Schreiber, Jason S., Karnak, David, Parsels, Leslie A., Parsels, Joshua D., Davis, Mary A., Zhao, Lili, Maybaum, Jonathan, Lawrence, Theodore S., Morgan, Meredith A.
Format: Artigo
Langue:Inglês
Publié: Neoplasia Press 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656803/
https://ncbi.nlm.nih.gov/pubmed/26585231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2015.09.006
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