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Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer

PURPOSE: While the addition of radiation to chemotherapy improves survival in patients with locally advanced pancreatic cancer, more effective therapies are urgently needed. Thus, we investigated the radiosensitizing efficacy of the novel drug combination of Wee1 and PARP1/2 [poly (ADP-ribose) polym...

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Detalhes bibliográficos
Main Authors: Karnak, David, Engelke, Carl G., Parsels, Leslie A., Kausar, Tasneem, Wei, Dongping, Robertson, Jordan R., Marsh, Katherine B., Davis, Mary A., Zhao, Lili, Maybaum, Jonathan, Lawrence, Theodore S., Morgan, Meredith A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184968/
https://ncbi.nlm.nih.gov/pubmed/25117293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1038
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