PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors

KRAS mutations in non-small cell lung cancer (NSCLC) cause increased levels of DNA damage and replication stress, suggesting that inhibition of the DNA damage response (DDR) is a promising strategy for radiosensitization of NSCLC. This study investigates the ability of a WEE1 inhibitor (AZD1775) and...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Parsels, Leslie A., Karnak, David, Parsels, Joshua D., Zhang, Qiang, Vélez-Padilla, Jonathan, Reichert, Zachery R., Wahl, Daniel R., Maybaum, Jonathan, O’Connor, Mark J., Lawrence, Theodore S., Morgan, Meredith A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805596/
https://ncbi.nlm.nih.gov/pubmed/29133592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0455
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