Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1

We have recently shown that inhibition of HRR (homologous recombination repair) by Chk1 (checkpoint kinase 1) inhibition radiosensitizes pancreatic cancer cells, and others have demonstrated that Chk1 inhibition selectively sensitizes p53 mutant tumor cells. Furthermore, PARP1 [poly (ADP-ribose) pol...

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Detaylı Bibliyografya
Asıl Yazarlar: Vance, Sean M, Liu, Erqi, Zhao, Lili, Parsels, Joshua D, Parsels, Leslie A, Brown, Jeffrey L, Maybaum, Jonathan, Lawrence, Theodore S, Morgan, Meredith A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Landes Bioscience 2011
Konular:
Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272262/
https://ncbi.nlm.nih.gov/pubmed/22134241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.24.18661
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