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The contribution of DNA replication stress marked by high-intensity, pan-nuclear γH2AX staining to chemosensitization by CHK1 and WEE1 inhibitors
Small molecule inhibitors of the checkpoint proteins CHK1 and WEE1 are currently in clinical development in combination with the antimetabolite gemcitabine. It is unclear, however, if there is a therapeutic advantage to CHK1 vs. WEE1 inhibition for chemosensitization. The goals of this study were to...
সংরক্ষণ করুন:
| প্রকাশিত: | Cell Cycle |
|---|---|
| প্রধান লেখক: | , , , , , |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
Taylor & Francis
2018
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6110577/ https://ncbi.nlm.nih.gov/pubmed/29895190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1475827 |
| ট্যাগগুলো: |
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