Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry

In order to determine the relative contribution of checkpoint abrogation and subsequent aberrant mitotic entry to gemcitabine chemosensitization by CHK1 inhibition, we established a model utilizing the CDK inhibitors roscovitine or purvalanol A to re-establish cell cycle arrest and prevent aberrant...

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Veröffentlicht in:Cell Cycle
Hauptverfasser: Parsels, Leslie A., Tanska, Daria M., Parsels, Joshua D., Zabludoff, Sonya D., Cuneo, Kyle C., Lawrence, Theodore S., Maybaum, Jonathan, Morgan, Meredith A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2016
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845922/
https://ncbi.nlm.nih.gov/pubmed/26890478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1148841
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