Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry

In order to determine the relative contribution of checkpoint abrogation and subsequent aberrant mitotic entry to gemcitabine chemosensitization by CHK1 inhibition, we established a model utilizing the CDK inhibitors roscovitine or purvalanol A to re-establish cell cycle arrest and prevent aberrant...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Parsels, Leslie A., Tanska, Daria M., Parsels, Joshua D., Zabludoff, Sonya D., Cuneo, Kyle C., Lawrence, Theodore S., Maybaum, Jonathan, Morgan, Meredith A.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845922/
https://ncbi.nlm.nih.gov/pubmed/26890478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1148841
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