Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor, MK8776

PURPOSE: The combination of radiation with chemotherapy is the most effective therapy for unresectable pancreatic cancer. To improve upon this regimen, we combined the selective Chk1 inhibitor, MK8776 with gemcitabine-based chemoradiation in preclinical pancreatic cancer models. EXPERIMENTAL DESIGN:...

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Main Authors: Engelke, Carl G., Parsels, Leslie A., Qian, Yushen, Zhang, Qiang, Karnak, David, Robertson, Jordan R., Tanska, Daria M., Wei, Dongping, Davis, Mary A., Parsels, Joshua D., Zhao, Lili, Greenson, Joel K, Lawrence, Theodore S., Maybaum, Jonathan, Morgan, Meredith A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745540/
https://ncbi.nlm.nih.gov/pubmed/23804422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3748
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