MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease

Bằng Liverton, Nigel J., Carroll, Steven S., DiMuzio, Jillian, Fandozzi, Christine, Graham, Donald J., Hazuda, Daria, Holloway, M. Katherine, Ludmerer, Steven W., McCauley, John A., McIntyre, Charles J., Olsen, David B., Rudd, Michael T., Stahlhut, Mark, Vacca, Joseph P.
Được phát hành 2010

Preclinical pharmacology and pharmacokinetics of CERC‐301, a GluN2B‐selective N‐methyl‐D‐aspartate receptor antagonist

Bằng Garner, Rachel, Gopalakrishnan, Shobha, McCauley, John A., Bednar, Rodney A., Gaul, Stanley L., Mosser, Scott D., Kiss, Laszlo, Lynch, Joseph J., Patel, Shil, Fandozzi, Christine, Lagrutta, Armando, Briscoe, Richard, Liverton, Nigel J., Paterson, Blake M., Vornov, James J., Mazhari, Reza
Xuất bản năm Pharmacol Res Perspect (2015)

Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure

Bằng Rudd, Michael T., McCauley, John A., Butcher, John W., Romano, Joseph J., McIntyre, Charles J., Nguyen, Kevin T., Gilbert, Kevin F., Bush, Kimberly J., Holloway, M. Katharine, Swestock, John, Wan, Bang-Lin, Carroll, Steven S., DiMuzio, Jillian M., Graham, Donald J., Ludmerer, Steven W., Stahlhut, Mark W., Fandozzi, Christine M., Trainor, Nicole, Olsen, David B., Vacca, Joseph P., Liverton, Nigel J.
Được phát hành 2011

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Bằng Summa, Vincenzo, Ludmerer, Steven W., McCauley, John A., Fandozzi, Christine, Burlein, Christine, Claudio, Giuliano, Coleman, Paul J., DiMuzio, Jillian M., Ferrara, Marco, Di Filippo, Marcello, Gates, Adam T., Graham, Donald J., Harper, Steven, Hazuda, Daria J., McHale, Carolyn, Monteagudo, Edith, Pucci, Vincenzo, Rowley, Michael, Rudd, Michael T., Soriano, Aileen, Stahlhut, Mark W., Vacca, Joseph P., Olsen, David B., Liverton, Nigel J., Carroll, Steven S.
Được phát hành 2012

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Bằng Summa, Vincenzo, Ludmerer, Steven W., McCauley, John A., Fandozzi, Christine, Burlein, Christine, Claudio, Giuliano, Coleman, Paul J., DiMuzio, Jillian M., Ferrara, Marco, Filippo, Marcello Di, Gates, Adam T., Graham, Donald J., Harper, Steven, Hazuda, Daria J., Huang, Qian, McHale, Carolyn, Monteagudo, Edith, Pucci, Vincenzo, Rowley, Michael, Rudd, Michael T., Soriano, Aileen, Stahlhut, Mark W., Vacca, Joseph P., Olsen, David B., Liverton, Nigel J., Carroll, Steven S.
Được phát hành 2014

Novel Quinoline-Based P2–P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors

Bằng Shah, Unmesh, Jayne, Charles, Chackalamannil, Samuel, Velázquez, Francisco, Guo, Zhuyan, Buevich, Alexei, Howe, John A., Chase, Robert, Soriano, Aileen, Agrawal, Sony, Rudd, Michael T., McCauley, John A., Liverton, Nigel J., Romano, Joseph, Bush, Kimberly, Coleman, Paul J., Grisé-Bard, Christiane, Brochu, Marie-Christine, Charron, Sylvie, Aulakh, Virender, Bachand, Benoit, Beaulieu, Patrick, Zaghdane, Helmi, Bhat, Sathesh, Han, Yongxin, Vacca, Joseph P., Davies, Ian W., Weber, Ann E., Venkatraman, Srikanth
Được phát hành 2014

Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors

Bằng Bungard, Christopher J., Williams, Peter D., Schulz, Jurgen, Wiscount, Catherine M., Holloway, M. Katharine, Loughran, H. Marie, Manikowski, Jesse J., Su, Hua-Poo, Bennett, David J., Chang, Lehua, Chu, Xin-Jie, Crespo, Alejandro, Dwyer, Michael P., Keertikar, Kartik, Morriello, Gregori J., Stamford, Andrew W., Waddell, Sherman T., Zhong, Bin, Hu, Bin, Ji, Tao, Diamond, Tracy L., Bahnck-Teets, Carolyn, Carroll, Steven S., Fay, John F., Min, Xu, Morris, William, Ballard, Jeanine E., Miller, Michael D., McCauley, John A.
Xuất bản năm ACS Med Chem Lett (2017)

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle

Bằng Favuzza, Paola, de Lera Ruiz, Manuel, Thompson, Jennifer K., Triglia, Tony, Ngo, Anna, Steel, Ryan W.J., Vavrek, Marissa, Christensen, Janni, Healer, Julie, Boyce, Christopher, Guo, Zhuyan, Hu, Mengwei, Khan, Tanweer, Murgolo, Nicholas, Zhao, Lianyun, Penington, Jocelyn Sietsma, Reaksudsan, Kitsanapong, Jarman, Kate, Dietrich, Melanie H., Richardson, Lachlan, Guo, Kai-Yuan, Lopaticki, Sash, Tham, Wai-Hong, Rottmann, Matthias, Papenfuss, Tony, Robbins, Jonathan A., Boddey, Justin A., Sleebs, Brad E., Sabroux, Hélène Jousset, McCauley, John A., Olsen, David B., Cowman, Alan F.
Xuất bản năm Cell Host Microbe (2020)

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

Bằng Harper, Steven, McCauley, John A., Rudd, Michael T., Ferrara, Marco, DiFilippo, Marcello, Crescenzi, Benedetta, Koch, Uwe, Petrocchi, Alessia, Holloway, M. Katharine, Butcher, John W., Romano, Joseph J., Bush, Kimberly J., Gilbert, Kevin F., McIntyre, Charles J., Nguyen, Kevin T., Nizi, Emanuela, Carroll, Steven S., Ludmerer, Steven W., Burlein, Christine, DiMuzio, Jillian M., Graham, Donald J., McHale, Carolyn M., Stahlhut, Mark W., Olsen, David B., Monteagudo, Edith, Cianetti, Simona, Giuliano, Claudio, Pucci, Vincenzo, Trainor, Nicole, Fandozzi, Christine M., Rowley, Michael, Coleman, Paul J., Vacca, Joseph P., Summa, Vincenzo, Liverton, Nigel J.
Được phát hành 2012

Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group

Bằng Bungard, Christopher J., Williams, Peter D., Ballard, Jeanine E., Bennett, David J., Beaulieu, Christian, Bahnck-Teets, Carolyn, Carroll, Steve S., Chang, Ronald K., Dubost, David C., Fay, John F., Diamond, Tracy L., Greshock, Thomas J., Hao, Li, Holloway, M. Katharine, Felock, Peter J., Gesell, Jennifer J., Su, Hua-Poo, Manikowski, Jesse J., McKay, Daniel J., Miller, Mike, Min, Xu, Molinaro, Carmela, Moradei, Oscar M., Nantermet, Philippe G., Nadeau, Christian, Sanchez, Rosa I., Satyanarayana, Tummanapalli, Shipe, William D., Singh, Sanjay K., Truong, Vouy Linh, Vijayasaradhi, Sivalenka, Wiscount, Catherine M., Vacca, Joseph P., Crane, Sheldon N., McCauley, John A.
Xuất bản năm ACS Med Chem Lett (2016)