Identification of Amides as Carboxylic Acid Surrogates for Quinolizidinone-Based M(1) Positive Allosteric Modulators

par Kuduk, Scott D., Chang, Ronald K., Greshock, Thomas J., Ray, William J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark T.
Publié 2012

Quinolizidinone Carboxylic Acids as CNS Penetrant, Selective M(1) Allosteric Muscarinic Receptor Modulators

par Kuduk, Scott D., Chang, Ronald K., Di Marco, Christina N., Ray, William J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark T.
Publié 2010

MK-7622: A First-in-Class M(1) Positive Allosteric Modulator Development Candidate

par Beshore, Douglas C., N. Di Marco, Christina, Chang, Ronald K., Greshock, Thomas J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Fuerst, Joy, Hartman, George D., Bilodeau, Mark T., Ray, William J., Kuduk, Scott D.
Publié dans ACS Med Chem Lett (2018)

Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group

par Bungard, Christopher J., Williams, Peter D., Ballard, Jeanine E., Bennett, David J., Beaulieu, Christian, Bahnck-Teets, Carolyn, Carroll, Steve S., Chang, Ronald K., Dubost, David C., Fay, John F., Diamond, Tracy L., Greshock, Thomas J., Hao, Li, Holloway, M. Katharine, Felock, Peter J., Gesell, Jennifer J., Su, Hua-Poo, Manikowski, Jesse J., McKay, Daniel J., Miller, Mike, Min, Xu, Molinaro, Carmela, Moradei, Oscar M., Nantermet, Philippe G., Nadeau, Christian, Sanchez, Rosa I., Satyanarayana, Tummanapalli, Shipe, William D., Singh, Sanjay K., Truong, Vouy Linh, Vijayasaradhi, Sivalenka, Wiscount, Catherine M., Vacca, Joseph P., Crane, Sheldon N., McCauley, John A.
Publié dans ACS Med Chem Lett (2016)