Identification of Amides as Carboxylic Acid Surrogates for Quinolizidinone-Based M(1) Positive Allosteric Modulators

[Image: see text] Selective activation of the M(1) muscarinic receptor via positive allosteric modulation represents an approach to treat the cognitive decline in patients with Alzheimer's disease. A series of amides were examined as a replacement for the carboxylic acid moiety in a class of qu...

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Detalhes bibliográficos
Main Authors: Kuduk, Scott D., Chang, Ronald K., Greshock, Thomas J., Ray, William J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025801/
https://ncbi.nlm.nih.gov/pubmed/24900430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300280g
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