Discovery of Naphthyl-Fused 5-Membered Lactams as a New Class of M(1) Positive Allosteric Modulators

[Image: see text] Selective activation of the M(1) muscarinic receptor via positive allosteric modulation represents an original approach to treat the cognitive decline in patients with Alzheimer’s disease. A series of naphthyl-fused 5-membered lactams were identified as a new class of M(1) positive...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Yang, Zhi-Qiang, Shu, Youheng, Ma, Lei, Wittmann, Marion, Ray, William J., Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark T., Kuduk, Scott D.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2014
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027734/
https://ncbi.nlm.nih.gov/pubmed/24900888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500055h
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires