Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates

[Image: see text] Lomibuvir (1) is a non-nucleoside, allosteric inhibitor of the hepatitis C virus NS5B polymerase with demonstrated clinical efficacy. Further development efforts within this class of inhibitor focused on improving the antiviral activity and physicochemical and pharmacokinetic prope...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Li, Pan, Dorsch, Warren, Lauffer, David J., Bilimoria, Darius, Chauret, Nathalie, Court, John J., Das, Sanjoy Kumar, Denis, Francois, Mani, Nagraj, Nanthakumar, Suganthini, Nicolas, Olivier, Rao, B. Govinda, Ronkin, Steven, Selliah, Subajini, Shawgo, Rebecca S., Stearns, Ralph, Tang, Qing, Waal, Nathan D., Green, Jeremy
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5304295/
https://ncbi.nlm.nih.gov/pubmed/28197321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00479
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker