Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors

[Image: see text] The discovery of potent thienoimidazole-based HCV NS5A inhibitors is herein reported. A novel method to access the thienoimidazole [5,5]-bicyclic system is disclosed. This method gave access to a common key intermediate (6) that was engaged in Suzuki or Sonogashira reactions with c...

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Detalhes bibliográficos
Main Authors: Giroux, Simon, Xu, Jinwang, Reddy, T. Jagadeeswar, Morris, Mark, Cottrell, Kevin M., Cadilhac, Caroline, Henderson, James A., Nicolas, Oliver, Bilimoria, Darius, Denis, Francois, Mani, Nagraj, Ewing, Nigel, Shawgo, Rebecca, L’Heureux, Lucille, Selliah, Subajini, Chan, Laval, Chauret, Nathalie, Berlioz-Seux, Francoise, Namchuk, Mark N., Grillot, Anne-Laure, Bennani, Youssef L., Das, Sanjoy K., Maxwell, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027595/
https://ncbi.nlm.nih.gov/pubmed/24900811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300461f
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