Nonstructural Protein 5A (NS5A) and Human Replication Protein A Increase the Processivity of Hepatitis C Virus NS5B Polymerase Activity In Vitro

The precise role(s) and topological organization of different factors in the hepatitis C virus (HCV) RNA replication complex are not well understood. In order to elucidate the role of viral and host proteins in HCV replication, we have developed a novel in vitro replication system that utilizes a ro...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Mani, Nagraj, Yuzhakov, Alexander, Yuzhakov, Olga, Coll, Joyce T., Black, Jim, Saxena, Kumkum, Fulghum, John R., Lippke, Judith A., Rao, B. Govinda, Rijnbrand, Rene, Kwong, Ann D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301100/
https://ncbi.nlm.nih.gov/pubmed/25320291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01677-14
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