The HCV Revolution Did Not Happen Overnight

por Kwong, Ann D.
Publicado em 2014

Combination of a Hepatitis C Virus NS3-NS4A Protease Inhibitor and Alpha Interferon Synergistically Inhibits Viral RNA Replication and Facilitates Viral RNA Clearance in Replicon C...

por Lin, Kai, Kwong, Ann D., Lin, Chao
Publicado em 2004

Viral and cellular RNA helicases as antiviral targets

por Kwong, Ann D., Rao, B. Govinda, Jeang, Kuan-Teh
Publicado no Nat Rev Drug Discov (2005)

VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon Cells

por Lin, Kai, Perni, Robert B., Kwong, Ann D., Lin, Chao
Publicado em 2006

Restoration of the Activated Rig-I Pathway in Hepatitis C Virus (HCV) Replicon Cells by HCV Protease, Polymerase, and NS5A Inhibitors In Vitro at Clinically Relevant Concentrations

por Kalkeri, Gururaj, Lin, Chao, Gopilan, Jenna, Sloan, Kevin, Rijnbrand, Rene, Kwong, Ann D.
Publicado em 2013

Compensatory substitutions in the HCV NS3/4A protease cleavage sites are not observed in patients treated unsuccessfully with telaprevir combination treatment

por Sullivan, James C, Zhang, Eileen Z, Bartels, Doug J, Tigges, Ann, Dorrian, Jennifer L, Kwong, Ann D, Kieffer, Tara L
Publicado em 2012

A Multi-Variant, Viral Dynamic Model of Genotype 1 HCV to Assess the in vivo Evolution of Protease-Inhibitor Resistant Variants

por Adiwijaya, Bambang S., Herrmann, Eva, Hare, Brian, Kieffer, Tara, Lin, Chao, Kwong, Ann D., Garg, Varun, Randle, John C. R., Sarrazin, Christoph, Zeuzem, Stefan, Caron, Paul R.
Publicado em 2010

Nonstructural Protein 5A (NS5A) and Human Replication Protein A Increase the Processivity of Hepatitis C Virus NS5B Polymerase Activity In Vitro

por Mani, Nagraj, Yuzhakov, Alexander, Yuzhakov, Olga, Coll, Joyce T., Black, Jim, Saxena, Kumkum, Fulghum, John R., Lippke, Judith A., Rao, B. Govinda, Rijnbrand, Rene, Kwong, Ann D.
Publicado no J Virol (2014)

Hepatitis C Virus Variants with Decreased Sensitivity to Direct-Acting Antivirals (DAAs) Were Rarely Observed in DAA-Naive Patients prior to Treatment

por Bartels, Doug J., Sullivan, James C., Zhang, Eileen Z., Tigges, Ann M., Dorrian, Jennifer L., De Meyer, Sandra, Takemoto, Darin, Dondero, Elizabeth, Kwong, Ann D., Picchio, Gaston, Kieffer, Tara L.
Publicado em 2013

Phenotypic Characterization of Resistant Val(36) Variants of Hepatitis C Virus NS3-4A Serine Protease

por Zhou, Yi, Bartels, Doug J., Hanzelka, Brian L., Müh, Ute, Wei, Yunyi, Chu, Hui-May, Tigges, Ann M., Brennan, Debra L., Rao, B. Govinda, Swenson, Lora, Kwong, Ann D., Lin, Chao
Publicado em 2008

Telaprevir-based Treatment Effects on Hepatitis C Virus in Liver and Blood

por Talal, Andrew H, Dimova, Rositsa B, Zhang, Eileen Z., Jiang, Min, Penney, Marina S., Sullivan, James C., Botfield, Martyn C., Chakilam, Ananthsrinivas, Sawant, Rishikesh, Cervini, Christine M., Zeremski, Marija, Jacobson, Ira M., Kwong, Ann D.
Publicado no Hepatology (2014)

Hepatitis C Viral Evolution in Genotype 1 Treatment-Naïve and Treatment-Experienced Patients Receiving Telaprevir-Based Therapy in Clinical Trials

por Kieffer, Tara L., De Meyer, Sandra, Bartels, Doug J., Sullivan, James C., Zhang, Eileen Z., Tigges, Ann, Dierynck, Inge, Spanks, Joan, Dorrian, Jennifer, Jiang, Min, Adiwijaya, Bambang, Ghys, Anne, Beumont, Maria, Kauffman, Robert S., Adda, Nathalie, Jacobson, Ira M., Sherman, Kenneth E., Zeuzem, Stefan, Kwong, Ann D., Picchio, Gaston
Publicado em 2012

Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit

por Byrn, Randal A., Jones, Steven M., Bennett, Hamilton B., Bral, Chris, Clark, Michael P., Jacobs, Marc D., Kwong, Ann D., Ledeboer, Mark W., Leeman, Joshua R., McNeil, Colleen F., Murcko, Mark A., Nezami, Azin, Perola, Emanuele, Rijnbrand, Rene, Saxena, Kumkum, Tsai, Alice W., Zhou, Yi, Charifson, Paul S.
Publicado no Antimicrob Agents Chemother (2015)

Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease

por Perni, Robert B., Almquist, Susan J., Byrn, Randal A., Chandorkar, Gurudatt, Chaturvedi, Pravin R., Courtney, Lawrence F., Decker, Caroline J., Dinehart, Kirk, Gates, Cynthia A., Harbeson, Scott L., Heiser, Angela, Kalkeri, Gururaj, Kolaczkowski, Elaine, Lin, Kai, Luong, Yu-Ping, Rao, B. Govinda, Taylor, William P., Thomson, John A., Tung, Roger D., Wei, Yunyi, Kwong, Ann D., Lin, Chao
Publicado em 2006