VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon Cells

Por Lin, Kai, Perni, Robert B., Kwong, Ann D., Lin, Chao
Publicado em 2006

Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

Por King, Robert W., Ladner, Stephanie K., Miller, Thomas J., Zaifert, Katie, Perni, Robert B., Conway, Samuel C., Otto, Michael J.
Publicado em 1999

Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

Por King, Robert W., Ladner, Stephanie K., Miller, Thomas J., Zaifert, Katie, Perni, Robert B., Conway, Sameul C., Otto, Michael J.
Publicado em 1998

SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR

Por Dai, Han, Kustigian, Lauren, Carney, David, Case, April, Considine, Thomas, Hubbard, Basil P., Perni, Robert B., Riera, Thomas V., Szczepankiewicz, Bruce, Vlasuk, George P., Stein, Ross L.
Publicado em 2010

Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes

Por Jin, Lei, Wei, Wentao, Jiang, Yaobin, Peng, Hao, Cai, Jianhua, Mao, Chen, Dai, Han, Choy, Wendy, Bemis, Jean E., Jirousek, Michael R., Milne, Jill C., Westphal, Christoph H., Perni, Robert B.
Publicado em 2009

Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3

Por Jin, Lei, Galonek, Heidi, Israelian, Kristine, Choy, Wendy, Morrison, Michael, Xia, Yu, Wang, Xiaohong, Xu, Yihua, Yang, Yuecheng, Smith, Jesse J, Hoffmann, Ethan, Carney, David P, Perni, Robert B, Jirousek, Michael R, Bemis, Jean E, Milne, Jill C, Sinclair, David A, Westphal, Christoph H
Publicado em 2009

Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease

Por Perni, Robert B., Almquist, Susan J., Byrn, Randal A., Chandorkar, Gurudatt, Chaturvedi, Pravin R., Courtney, Lawrence F., Decker, Caroline J., Dinehart, Kirk, Gates, Cynthia A., Harbeson, Scott L., Heiser, Angela, Kalkeri, Gururaj, Kolaczkowski, Elaine, Lin, Kai, Luong, Yu-Ping, Rao, B. Govinda, Taylor, William P., Thomson, John A., Tung, Roger D., Wei, Yunyi, Kwong, Ann D., Lin, Chao
Publicado em 2006

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Por Milne, Jill C., Lambert, Philip D., Schenk, Simon, Carney, David P., Smith, Jesse J., Gagne, David J., Jin, Lei, Boss, Olivier, Perni, Robert B., Vu, Chi B., Bemis, Jean E., Xie, Roger, Disch, Jeremy S., Ng, Pui Yee, Nunes, Joseph J., Lynch, Amy V., Yang, Hongying, Galonek, Heidi, Israelian, Kristine, Choy, Wendy, Iffland, Andre, Lavu, Siva, Medvedik, Oliver, Sinclair, David A., Olefsky, Jerrold M., Jirousek, Michael R., Elliott, Peter J., Westphal, Christoph H.
Publicado em 2007

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

Por Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.
Publicado no Nat Commun (2015)

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Por Hubbard, Basil P., Gomes, Ana P., Dai, Han, Li, Jun, Case, April W., Considine, Thomas, Riera, Thomas V., Lee, Jessica E., Sook Yen, E, Lamming, Dudley W., Pentelute, Bradley L., Schuman, Eli R., Stevens, Linda A., Ling, Alvin J. Y., Armour, Sean M., Michan, Shaday, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Blum, Charles A., Disch, Jeremy S., Ng, Pui Yee, Howitz, Konrad T., Rolo, Anabela P., Hamuro, Yoshitomo, Moss, Joel, Perni, Robert B., Ellis, James L., Vlasuk, George P., Sinclair, David A.
Publicado em 2013