Antitussive activity of sigma-1 receptor agonists in the guinea-pig

Por Brown, Claire, Fezoui, Malika, Selig, William M, Schwartz, Carl E, Ellis, James L
Publicado em 2003

Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Por Jiang, Mali, Zheng, Jennifer, Peng, Qi, Hou, Zhipeng, Zhang, Jiangyang, Mori, Susumu, Ellis, James L, Vlasuk, George P, Fries, Harvey, Suri, Vipin, Duan, Wenzhen
Publicado no Ann Clin Transl Neurol (2014)

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism

Por Hubbard, Basil P, Loh, Christine, Gomes, Ana P, Li, Jun, Lu, Quinn, Doyle, Taylor LG, Disch, Jeremy S, Armour, Sean M, Ellis, James L, Vlasuk, George P, Sinclair, David A
Publicado em 2013

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

Por Boerma, Marjan, Fu, Qiang, Wang, Junru, Loose, David S., Bartolozzi, Alessandra, Ellis, James L., McGonigle, Sharon, Paradise, Elsa, Sweetnam, Paul, Fink, Louis M., Vozenin-Brotons, Marie-Catherine, Hauer-Jensen, Martin
Publicado em 2008

Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1

Por Bellet, Marina M., Nakahata, Yasukazu, Boudjelal, Mohamed, Watts, Emma, Mossakowska, Danuta E., Edwards, Kenneth A., Cervantes, Marlene, Astarita, Giuseppe, Loh, Christine, Ellis, James L., Vlasuk, George P., Sassone-Corsi, Paolo
Publicado em 2013

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

Por Yang, Hongying, Zhang, Wei, Pan, Heng, Feldser, Heidi G., Lainez, Elden, Miller, Christine, Leung, Stewart, Zhong, Zhong, Zhao, Huizhen, Sweitzer, Sharon, Considine, Thomas, Riera, Thomas, Suri, Vipin, White, Brian, Ellis, James L., Vlasuk, George P., Loh, Christine
Publicado em 2012

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet

Por Mitchell, Sarah J., Martin-Montalvo, Alejandro, Mercken, Evi M., Palacios, Hector H., Ward, Theresa M., Abulwerdi, Gelareh, Minor, Robin K., Vlasuk, George P., Ellis, James L., Sinclair, David A., Dawson, John, Allison, David B., Zhang, Yongqing, Becker, Kevin G., Bernier, Michel, de Cabo, Rafael
Publicado em 2014

The Sirt1 activator SRT3025 provides atheroprotection in Apoe(−/−) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

Por Miranda, Melroy X., van Tits, Lambertus J., Lohmann, Christine, Arsiwala, Tasneem, Winnik, Stephan, Tailleux, Anne, Stein, Sokrates, Gomes, Ana P., Suri, Vipin, Ellis, James L., Lutz, Thomas A., Hottiger, Michael O., Sinclair, David A., Auwerx, Johan, Schoonjans, Kristina, Staels, Bart, Lüscher, Thomas F., Matter, Christian M.
Publicado no Eur Heart J (2015)

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

Por Mercken, Evi M, Mitchell, Sarah J, Martin-Montalvo, Alejandro, Minor, Robin K, Almeida, Maria, Gomes, Ana P, Scheibye-Knudsen, Morten, Palacios, Hector H, Licata, Jordan J, Zhang, Yongqing, Becker, Kevin G, Khraiwesh, Husam, González-Reyes, José A, Villalba, José M, Baur, Joseph A, Elliott, Peter, Westphal, Christoph, Vlasuk, George P, Ellis, James L, Sinclair, David A, Bernier, Michel, de Cabo, Rafael
Publicado em 2014

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

Por Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.
Publicado no Nat Commun (2015)

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Por Hubbard, Basil P., Gomes, Ana P., Dai, Han, Li, Jun, Case, April W., Considine, Thomas, Riera, Thomas V., Lee, Jessica E., Sook Yen, E, Lamming, Dudley W., Pentelute, Bradley L., Schuman, Eli R., Stevens, Linda A., Ling, Alvin J. Y., Armour, Sean M., Michan, Shaday, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Blum, Charles A., Disch, Jeremy S., Ng, Pui Yee, Howitz, Konrad T., Rolo, Anabela P., Hamuro, Yoshitomo, Moss, Joel, Perni, Robert B., Ellis, James L., Vlasuk, George P., Sinclair, David A.
Publicado em 2013

SRT1720 improves survival and healthspan of obese mice

Por Minor, Robin K., Baur, Joseph A., Gomes, Ana P., Ward, Theresa M., Csiszar, Anna, Mercken, Evi M., Abdelmohsen, Kotb, Shin, Yu-Kyong, Canto, Carles, Scheibye-Knudsen, Morten, Krawczyk, Melissa, Irusta, Pablo M., Martín-Montalvo, Alejandro, Hubbard, Basil P., Zhang, Yongqing, Lehrmann, Elin, White, Alexa A., Price, Nathan L., Swindell, William R., Pearson, Kevin J., Becker, Kevin G., Bohr, Vilhelm A., Gorospe, Myriam, Egan, Josephine M., Talan, Mark I., Auwerx, Johan, Westphal, Christoph H., Ellis, James L., Ungvari, Zoltan, Vlasuk, George P., Elliott, Peter J., Sinclair, David A., de Cabo, Rafael
Publicado em 2011

CORRIGENDUM: SRT1720 improves survival and healthspan of obese mice

Por Minor, Robin K., Baur, Joseph A., Gomes, Ana P., Ward, Theresa M., Csiszar, Anna, Mercken, Evi M., Abdelmohsen, Kotb, Shin, Yu-Kyong, Canto, Carles, Scheibye-Knudsen, Morten, Krawczyk, Melissa, Irusta, Pablo M., Martín-Montalvo, Alejandro, Hubbard, Basil P., Zhang, Yongqing, Lehrmann, Elin, White, Alexa A., Price, Nathan L., Swindell, William R., Pearson, Kevin J., Becker, Kevin G., Bohr, Vilhelm A., Gorospe, Myriam, Egan, Josephine M., Talan, Mark I., Auwerx, Johan, Westphal, Christoph H., Ellis, James L., Ungvari, Zoltan, Vlasuk, George P., Elliott, Peter J., Sinclair, David A., de Cabo, Rafael
Publicado em 2013

Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes

Por Biason-Lauber, Anna, Böni-Schnetzler, Marianne, Hubbard, Basil P., Bouzakri, Karim, Brunner, Andrea, Cavelti-Weder, Claudia, Keller, Cornelia, Meyer-Böni, Monika, Meier, Daniel T., Brorsson, Caroline, Timper, Katharina, Leibowitz, Gil, Patrignani, Andrea, Bruggmann, Remy, Boily, Gino, Zulewski, Henryk, Geier, Andreas, Cermak, Jennifer M., Elliott, Peter, Ellis, James L., Westphal, Christoph, Knobel, Urs, Eloranta, Jyrki J., Kerr-Conte, Julie, Pattou, François, Konrad, Daniel, Matter, Christian M., Fontana, Adriano, Rogler, Gerhard, Schlapbach, Ralph, Regairaz, Camille, Carballido, José M., Glaser, Benjamin, McBurney, Michael W., Pociot, Flemming, Sinclair, David A., Donath, Marc Y.
Publicado em 2013