A Kinetic Alignment of Orthologous Inosine-5′-monophosphate Dehydrogenases

por Riera, Thomas V., Wang, Wen, Josephine, Helen R., Hedstrom, Lizbeth
Publicado 2008

Allosteric activation via kinetic control: Potassium accelerates a conformational change in IMP dehydrogenase()

por Riera, Thomas V., Zheng, Lianqing, Josephine, Helen R., Min, Donghong, Yang, Wei, Hedstrom, Lizbeth
Publicado 2011

Quantitative Analysis of Receptor Tyrosine Kinase-Effector Coupling at Functionally Relevant Stimulus Levels

por Li, Simin, Bhave, Devayani, Chow, Jennifer M., Riera, Thomas V., Schlee, Sandra, Rauch, Simone, Atanasova, Mariya, Cate, Richard L., Whitty, Adrian
Publicado en J Biol Chem (2015)

The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity

por MacPherson, Iain S., Kirubakaran, Sivapriya, Gorla, Suresh Kumar, Riera, Thomas V., D'Aquino, J. Alejandro, Zhang, Minjia, Cuny, Gregory D., Hedstrom, Lizbeth
Publicado 2010

Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against Cryptosporidiosis

por Umejiego, Nwakaso N., Gollapalli, Deviprasad, Sharling, Lisa, Volftsun, Anna, Lu, Jennifer, Benjamin, Nicole N., Stroupe, Adam H., Riera, Thomas V., Striepen, Boris, Hedstrom, Lizbeth
Publicado 2008

SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR

por Dai, Han, Kustigian, Lauren, Carney, David, Case, April, Considine, Thomas, Hubbard, Basil P., Perni, Robert B., Riera, Thomas V., Szczepankiewicz, Bruce, Vlasuk, George P., Stein, Ross L.
Publicado 2010

Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor

por Mitchell, Lorna H., Boriack-Sjodin, P. Ann, Smith, Sherri, Thomenius, Michael, Rioux, Nathalie, Munchhof, Michael, Mills, James E., Klaus, Christine, Totman, Jennifer, Riera, Thomas V., Raimondi, Alejandra, Jacques, Suzanne L., West, Kip, Foley, Megan, Waters, Nigel J., Kuntz, Kevin W., Wigle, Tim J., Scott, Margaret Porter, Copeland, Robert A., Smith, Jesse J., Chesworth, Richard
Publicado en ACS Med Chem Lett (2015)

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

por Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.
Publicado en Nat Commun (2015)

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

por Hubbard, Basil P., Gomes, Ana P., Dai, Han, Li, Jun, Case, April W., Considine, Thomas, Riera, Thomas V., Lee, Jessica E., Sook Yen, E, Lamming, Dudley W., Pentelute, Bradley L., Schuman, Eli R., Stevens, Linda A., Ling, Alvin J. Y., Armour, Sean M., Michan, Shaday, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Blum, Charles A., Disch, Jeremy S., Ng, Pui Yee, Howitz, Konrad T., Rolo, Anabela P., Hamuro, Yoshitomo, Moss, Joel, Perni, Robert B., Ellis, James L., Vlasuk, George P., Sinclair, David A.
Publicado 2013

Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation

por Thomenius, Michael J., Totman, Jennifer, Harvey, Darren, Mitchell, Lorna H., Riera, Thomas V., Cosmopoulos, Kat, Grassian, Alexandra R., Klaus, Christine, Foley, Megan, Admirand, Elizabeth A., Jahic, Haris, Majer, Christina, Wigle, Tim, Jacques, Suzanne L., Gureasko, Jodi, Brach, Dorothy, Lingaraj, Trupti, West, Kip, Smith, Sherri, Rioux, Nathalie, Waters, Nigel J., Tang, Cuyue, Raimondi, Alejandra, Munchhof, Michael, Mills, James E., Ribich, Scott, Porter Scott, Margaret, Kuntz, Kevin W., Janzen, William P., Moyer, Mikel, Smith, Jesse J., Chesworth, Richard, Copeland, Robert A., Boriack-Sjodin, P. Ann
Publicado en PLoS One (2018)