mTORC2 takes the longevity stAGE

Por Lamming, Dudley W.
Publicado em 2014

Hot topics at the intersection of aging and energetics: Diabetes/insulin resistance, Sirtuins, and the Microbiome

Por Lamming, Dudley W.
Publicado no F1000Res (2014)

Diminished mTOR signaling: a common mode of action for endocrine longevity factors

Por Lamming, Dudley W
Publicado no Springerplus (2014)

Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin and Beyond

Por Lamming, Dudley W.
Publicado no Cold Spring Harb Perspect Med (2016)

A radical role for TOR in longevity

Por Lamming, Dudley W., Sabatini, David M.
Publicado em 2011

A central role for mTOR in lipid homeostasis

Por Lamming, Dudley W., Sabatini, David M.
Publicado em 2013

The mechanistic Target of Rapamycin: The grand conducTOR of metabolism and aging

Por Kennedy, Brian K., Lamming, Dudley W.
Publicado no Cell Metab (2016)

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island

Por Arriola Apelo, Sebastian I., Lamming, Dudley W.
Publicado no J Gerontol A Biol Sci Med Sci (2016)

Pharmacologic Means of Extending Lifespan

Por Lamming, Dudley W., Sabatini, David M., Baur, Joseph A.
Publicado no J Clin Exp Pathol (2012)

MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae

Por Medvedik, Oliver, Lamming, Dudley W, Kim, Keyman D, Sinclair, David A
Publicado em 2007

Rapalogs and mTOR inhibitors as anti-aging therapeutics

Por Lamming, Dudley W., Ye, Lan, Sabatini, David M., Baur, Joseph A.
Publicado em 2013

Sex‐ and tissue‐specific changes in mTOR signaling with age in C57BL/6J mice

Por Baar, Emma L., Carbajal, Kathryn A., Ong, Irene M., Lamming, Dudley W.
Publicado no Aging Cell (2015)

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2

Por Ye, Lan, Varamini, Behzad, Lamming, Dudley W., Sabatini, David M., Baur, Joseph A.
Publicado em 2012

The role of protein arginine methylation in the formation of silent chromatin

Por Yu, Michael C., Lamming, Dudley W., Eskin, Julian A., Sinclair, David A., Silver, Pamela A.
Publicado em 2006

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

Por Lamming, Dudley W., Ye, Lan, Astle, Michael, Baur, Joseph A., Sabatini, David M., Harrison, David E.
Publicado em 2013

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice

Por Arriola Apelo, Sebastian I., Pumper, Cassidy P., Baar, Emma L., Cummings, Nicole E., Lamming, Dudley W.
Publicado no J Gerontol A Biol Sci Med Sci (2016)

RagA, but not RagB, is essential for embryonic development and adult mice

Por Efeyan, Alejo, Schweitzer, Lawrence D., Bilate, Angelina M., Chang, Steven, Kirak, Oktay, Lamming, Dudley W., Sabatini, David M.
Publicado em 2014

The TSC-mTOR pathway regulates macrophage polarization

Por Byles, Vanessa, Covarrubias, Anthony J., Ben-Sahra, Issam, Lamming, Dudley W., Sabatini, David M., Manning, Brendan D., Horng, Tiffany
Publicado em 2013

Rapamycin-induced metabolic defects are reversible in both lean and obese mice

Por Liu, Yuhong, Diaz, Vivian, Fernandez, Elizabeth, Strong, Randy, Ye, Lan, Baur, Joseph A., Lamming, Dudley W., Richardson, Arlan, Salmon, Adam B.
Publicado no Aging (Albany NY) (2014)

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model

Por Lamming, Dudley W., Cummings, Nicole E., Rastelli, Antonella L., Gao, Feng, Cava, Edda, Bertozzi, Beatrice, Spelta, Francesco, Pili, Roberto, Fontana, Luigi
Publicado no Oncotarget (2015)