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Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin and Beyond

Rapamycin is a Food and Drug Administration (FDA)-approved immunosuppressant and anticancer agent discovered in the soil of Easter Island in the early 1970s. Rapamycin is a potent and selective inhibitor of the mechanistic target of rapamycin (mTOR) protein kinase, which acts as a central integrator...

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Bibliographic Details
Published in:Cold Spring Harb Perspect Med
Main Author: Lamming, Dudley W.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852795/
https://ncbi.nlm.nih.gov/pubmed/27048303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a025924
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