Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2

Rapamycin, an inhibitor of mTOR complex 1 (mTORC1), improves insulin sensitivity in acute studies in vitro and in vivo by disrupting a negative feedback loop mediated by S6 kinase. We find that rapamycin has a clear biphasic effect on insulin sensitivity in C2C12 myotubes, with enhanced responsivene...

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Bibliographic Details
Main Authors: Ye, Lan, Varamini, Behzad, Lamming, Dudley W., Sabatini, David M., Baur, Joseph A.
Format: Artigo
Language:Inglês
Published: Frontiers Research Foundation 2012
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438685/
https://ncbi.nlm.nih.gov/pubmed/22973301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2012.00177
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