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Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin

mTOR, the mammalian target of rapamycin, is a critical node for control of cell growth and survival and has widely been implicated in cancer survival signals. mTOR exists in two complexes: mTORC1 and mTORC2. Phospholipase D (PLD) and its metabolite phosphatidic acid (PA) have been implicated in the...

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書誌詳細
主要な著者: Toschi, Alfredo, Lee, Evan, Xu, Limei, Garcia, Avalon, Gadir, Noga, Foster, David A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648237/
https://ncbi.nlm.nih.gov/pubmed/19114562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00782-08
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